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ACRP Certified Professional : ACRP-CP

ACRP-CP

Exam Code: ACRP-CP

Exam Name: ACRP Certified Professional Exam

Updated: Oct 03, 2026

Q & A: 127 Questions and Answers

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Professionalism and Ethical Practice15%- Professional standards
  • 1. Role responsibilities and boundaries
  • 2. Confidentiality and conflict of interest
- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections
- ICH Guidelines
  • 1. E11 Pediatric Trials
  • 2. E6(R2)/E6(R3) Good Clinical Practice
  • 3. E8 General Considerations for Clinical Trials
  • 4. E2A Expedited Reporting
  • 5. E9 Statistical Principles
Study Design and Conduct17%- Study planning
  • 1. Protocol development and amendments
  • 2. Sample size and statistical considerations
  • 3. Study population and eligibility criteria
- Study implementation
  • 1. Site selection and activation
  • 2. Investigational product management
  • 3. Study monitoring and oversight
Clinical Study Operations15%- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
Ethical and Participant Safety Considerations19%- Clinical care and management of research participants
  • 1. Standard of care vs protocol requirements
  • 2. Continuity of medical care
  • 3. Informed consent development and review
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
Data Management and Informatics17%- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
- Data quality control
  • 1. Data validation and cleaning
  • 2. Query management and resolution

ACRP Certified Professional Sample Questions:

Question #1
In addition to members who collectively have the qualifications and experience to review and evaluate the science, medical aspects, and ethics of the proposed trial, it is recommended that the IRB/IEC should include:

A. One member who is independent of the institution/trial site.
B. One member of the site's QA group.
C. One member whose primary area of interest is in the same scientific area.
D. A total of five members.


Question #2
A deferred consent can take place in which of the following situations?

A. Only when the PI approves such a consent process immediately prior to patient enrollment, regardless of the situation being classed as emergency.
B. Only when the PI approves such a consent process, regardless of the emergency situation described in the protocol.
C. In an emergency situation only, when this process is described in the protocol and has received permission from the ethics committee.
D. In an emergency situation only, even when this process is not described in the protocol, but the sponsor approves the consent process.


Question #3
During a mid-study sponsor audit of a clinical trial, the auditor notices that all of the protocol-required subject drug dosing diaries were incomplete. The effect of this will be the inability to:

A. Conduct safety analysis.
B. Validate protocol endpoints.
C. Evaluate study data.
D. Verify compliance with IP regimen.


Question #4
A quality assurance audit of the EDC system SOP revealed a deficiency. Which of the following is the MOST likely reason?

A. The frequency of data backup was not defined.
B. The number of users with access was not defined.
C. The list of comparable technology solutions was not included.
D. The number of unique eCRF templates was not specified.


Question #5
A representative from a regulatory authority shows up unannounced at a research site. After confirming their credentials, the representative requested to view the entire records, including identifiable information, from study XYZ that was closed out. Which of the following should the site personnel do next?

A. Deny the request until the sponsor approves.
B. Allow access to the entire records.
C. Consult with the IRB/IEC first.
D. Redact subject identification for privacy protection.


Solutions:

Question #1
Correct Answer: A
Question #2
Correct Answer: C
Question #3
Correct Answer: D
Question #4
Correct Answer: A
Question #5
Correct Answer: B

Related Certifications
ACRP Certified Professional
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